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Nootropics & Smart Drugs
 
Nootropic Ingredients
Video
Recommended Daily
Cofactors
Side Effects
Conflicts
Summary
 
Bacopa Monniera (Brahmi)

Some report taking it quiet high dosages of without issues:
"...personally bacopa in super high dose (1-2g two or three times a day) is really amazing for me!"
One day I mistakenly dumped about 2 grams Bacopa in my tea, which is quiet a mega dose, it was not an outstandingly negative or positive effect.

Cofactors

It has a notable synergistic effect with...
Green Tea
Ashwagandha
Milk Thistle
Curcumin
...according to 2009 study out of University of Colorado:
"...the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them... All components together, however, produced a strongly synergistic induction of around three- to ninefold in a dose-dependent manner, greatly exceeding the sum of the parts."
Ginkgo - according to medicinal traditions it can really help with brain fog in combination with other herbs, from Adaptogens:
"It is used in ayurvedic medicine to relieve “mental fog” caused by chronic cannabis smoking. It can be combined with other cerebral stimulants such as rosemary, bacopa, and ginkgo to help people with menopausal cloudy thinking, poor memory, attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD), and to speed up recovery from head trauma. "
Bacopa, St. John’s wort, Ginkgo, and Holy Basil can be a transformative cocktail for overcoming cognitive impairment. Consider this remarkable case documented in Adaptogens:
In one remarkable case from many years ago, I had an opportunity to use a similar formula with great success. A friend’s wife came down with bacterial meningitis. Luckily, they caught it early enough. She was rushed to the hospital and given intravenous antibiotics. Her life was saved and she was discharged from the hospital, but she still had severe cognitive problems. Her ability to hear, see, speak, and smell all were seriously impaired. She was unable to hold a conversation, work, or read; even food had a strange taste. Her doctors had done all they could do and advised her that these troubling symptoms would hopefully resolve after six to twelve months. I was asked to help at this point and recommended several nootropic and adaptogenic herbs. In two weeks, she reported significant improvement, and after a month on this formula, she stated that she was “back to normal, and maybe even better than that.” This case, although remarkable in its quick and total success, is not all that unusual and shows how herbs can offer significant benefits for many “untreatable conditions.” (p. 223)

Side Effects:

Bacopa is regarded as being very safe.
For many it's a downer. One Canadian biohacker reported insightfully:
"I've been using Bacopa... for 8 weeks with negative results...
Decreased Dopamine. Which results in decreased libido, lack of motivation, lack of energy, sleepiness, poor abstract thinking. Actually Bacopa decrease[s] significantly dopamine..."
Gastrointestinal - the one notable side effect observed is cramping.
The very mild side effects of a high dosage can include dry mouth, muscle fatigue, and nausea.

It’s not recommended to take Bacopa with chlorpromazine, a drug in the pharmaceutical family of perphenazine.

By Jonathan Roseland  Connect     Bacopa is another historical Adaptogenic herb, it has been used in India as a form of Ayurvedic medicine for thousands of years. Bacopa owes...
Bacopa Monniera (Brahmi)
Eleutherococcus Senticosus

Recommended Daily

It's a good idea to break up dosages between a dose first thing in the morning, and a noon or mid-afternoon dose. Taking it later in the evening may disturb sleep.
It's one Nootropic that you don't want to take in an attack dose, you'll want to start with a low dosage and work your way up, to quote Introspecta:
"Very low doses which are found in some Teas worked great for me but whenever I tried the supplements they were too stimulating and gave me anxiety. I was under the impression that Eleuthero didn't cause anxiety but was wrong."

Cofactors

The top cofactors as mentioned frequently in human studies are Rhodiola Rosea and Schisandra Chinensis together in Adapt-232.
A few redditors enthusiastically reported that it potentates Kratom, a none-Nootropic performance enhancer with a notoriously steep tolerance curve.

Side Effects

After reading numerous self experimentation reports of Eleuthero, I've come to the conclusion that the only side effect of Eleuthero you should be seriously worried about is anxiety or mania resulting from excessive dosage or combining with other stimulants. This is one Nootropic you don't want take at crazy doses or stack with a bunch of other things.
A German double blind study monitored the human study subjects for 5 months after dosing and noted no negative side effects.

Since it's a stimulant taking it with other stimulants like coffee is maybe not a great idea. Currently no known enzyme interactions that would interfere with pharmaceuticals.

By Jonathan Roseland Connect Eleutherococcus senticosus, is another historical Nootropic known for "invigorating qi and strengthening the spleen, tonifying kidney to relieve mental strain" in...
Eleutherococcus Senticosus
Rhodiola

Recommended Daily

  • 200 Milligrams - 600 Milligrams daily for extracts of at least 3% rosavins and 0.8-1% salidroside.
  • 100 - 170 Milligrams daily for 3.6% rosavin extract
  • 180 - 300 Milligrams daily for 2% rosavin extract

One study administered as much as 680 Milligrams daily to treat mild depression and negative side effects were not reported.
However, less is more with Rhodiola, if you take too high a dosage (especially with the higher percentage extracts) it has some contrary effects to what’s probably desired. So start with a low dosage as opposed to an attack dosage. As low as 50 milligrams daily to prevent fatigue.

Cofactors:

Racetams

A number of self experimenters report that it has a synergistic effect on memory and cognition with Piracetam. Based upon the glowing recommendation in Piracetam Protocol, I’m going to include Rhodiola in the Piracetam Protocol.

The Soviet Formula

From it’s space program and it’s wars in the rugged mountains of Afghanistan to its fierce spirit of athletic competition the Soviet Union made extreme performance demands of its citizenry. From the labs behind the iron curtain emerged a hardcore herbal formula for peak performance and resilience...

Also known as Adapt-232. A 2010 Double-blind, placebo-controlled Armenian study of 40 healthy women, came to some optimistic conclusions, from it’s abstract:
“The subjects in the ADAPT-232 group quickly (two hours after verum was taken) gained improved attention and increased speed and accuracy during stressful cognitive tasks, in comparison to placebo. There was also a tendency of ADAPT-232 to reduce percentage of errors, which means better accuracy, quality of the work, and degree of care in the volunteers under stressful conditions.”

The bad news... Is that if you want to try Adapt-232 you can’t. It’s not for sale anywhere. So I’ve decided to study the documentation, formulate it and will sell it, I encourage you to subscribe to our newsletter to be updated when it’s available.

Herbal Cofactors

For some it has a marvelous effect in combination with St. John’s Wort, to quote Sasha in the UK:
“I started taking 1 capsule of Rhodiola and 1 of St John's wort together twice daily. I can't fathom how these two plants work synergetically (perhaps someone here can enlighten me) but they sure do for me, I got better mood, more energy/stamina, and felt stimulated without feeling stressed or jittery. My concentration got better, and although I think I was intellectually stimulated I can't tell wether this kind of stimulation might be beneficial for someone who deals with important mental tasks.”

Side Effects:

Rhodiola rosea, when taken at high dosages has side effects typical of stimulant nootropics; restlessness, insomnia, irritability, and increased heart rate and possibly increased blood pressure. Don’t take it before bed.

No interactions are reported on WebMD.

By Jonathan Roseland  Connect    
This adaptogenic herbal stimulant has been used as an energy boosting agent in Russia and China for centuries. It stimulates the nervous system, helps with work, along with combating stress and fatigue. It also contains a number of phytochemicals, neuroprotective antioxidizing agents and is a stress reducing agent. ...
Rhodiola
Schisandra Chinensis

Cofactors

Most of the more promising placebo controlled human studies including Schisandra, were done on the Adapt-232 formula of which Schisandra is one third of, the other ingredients are the adaptogens Eleuthero and Rhodiola Rosea.
Sesamin
One of the human studies that demonstrated positive effect on blood flow was using Sesamin extract which is also a Lignan in conjunction with Schisandra extract.

Rhaponticum and schisandra enhance reading comprehension, aptitude, and speed.(p. 94) Talk about a reading lifehack!

Side Effects

Can include heartburn, acid indigestion and stomach pain.

It's been demonstrated to wash the drug Warfarin out of the body faster, diminishing Warfarin's effects.

By Jonathan Roseland Connect A delicious five flavored Adaptogen that has been used for thousands of years to Biohack Yin and Yang. A notable...
Schisandra Chinensis
Ginseng

Recommended Daily

Cofactors

Ginkgo Biloba
Together they had an exponential effect on alertness, relaxation and appetite. From a Bulgarian study:
"The favorable effects on learning and memory of the combination of [Panax Ginseng] plus [Ginkgo Biloba] and the other pharmacological activities inherent in the extracts characterize this combination, offered as Gincosan as a particularly promising drug in geriatric practice."
Rhodiola Rosea
Another excellent adaptogenic herb, debatably it has a powerful synergy with Ginseng.
Kai Xin San
Kai Xin San, is the delivering servant of Panax Ginseng in folk medicine annals, which a handful of Beijing studies agree with. A 2012 review out of the Hong Kong Polytechnic University emphasized the relative safety of taking Rhodiola as part of a smart drug stack:
"Being an adaptogen, Rhodiola rosea bears various pharmacological effects. It is particularly useful in that it does not interfere with other drugs nor have any adverse effects in the course of clinical trials..."

Side Effects

"Moreover, long -term use of the herb— especially in doses exceeding 3 grams a day— is cause for concern. Some adolescent boys and others who have taken megadoses of Panax ginseng to build strength and endurance have experienced estrogen-like effects, such as painful swelling of the breasts." [1]

By Jonathan Roseland  Connect     An adaptogenic medicinal herb of mythological potency for increasing stamina and a profound sense of well-being.
Ginseng
Ashwagandha
By Jonathan Roseland Connect The berry and root of the Ashwagandha plant can be extracted for a variety of useful medical uses; as a Nootropic it helps...
Ashwagandha