Coenzyme Q10

Coenzyme Q10

By Jonathan Roseland  Connect    

The Mitochondrial process that drives our trillions of individual cells and defines the grace with which we age has been a particularly hot arena of scientific research the past few years.

You can find +350 human studies specific to CoQ10 in the past 5 years on Pubmed. A essential chemical ingredient to the Mitochondrial process that powers our bodies on a cellular level with the production of Adenosine Triphosphate (ATP).

The Godfather of antiaging
, Ray Kurzwiel includes CoQ10 in his daily regimen of supplements and recommends it in his book Fantastic Voyage: Live Long Enough to Live Forever.


Ubiquinol vs Ubiquinone

There's two types of it, the original form of CoQ10 synthisized and supplemented was Ubiquinone, however it is difficult to absorb. Ubiquinol is more bioavaliable and found to be 40% more effective than Ubiquinone in reducing aging in animal studies and 90% more effective in human fatigue studies. Therefor we recommend the Ubiquinol form of the supplement.

It is sometimes criticized for it is high price although it has an impressive preponderance of human trials in comparison to other other drugs and supplements that benefit the same conditions.

Longetivity & Antiaging Properties




There is some debate as to weather it is a net positive or negative for longevity which seems to stem from a study of CoQ10 in worms wherein it acted as pro-oxidative and slightly decreased the lifespans of worms. Although a rat study found the opposite effect.

The Godfather of antiaging, Ray Kurzwiel includes CoQ10 in his daily regimen of supplements and recommends it in his book Fantastic Voyage: Live Long Enough to Live Forever.

For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract...

a 2008 Perdue University study of 10 human subjects, showed it decreased harmful age related arNOX levels:

...arNOX activity was reduced between 25 and 30% by a 3 x 60 mg daily dose Coenzyme Q10 supplementation. Inhibition was the result of Coenzyme Q10 presence.

The consensus is that it is lacking a decent study showing a clear effect on human longevity.

Immune Biohack

To quote "The Miracle Nutrient Coenzyme Q10" by Emile G. Bliznakov MD

That CoQ plays a crucial role in aging is beyond doubt. The same applies to CoQ's role in the immune system. And there is a vital connection between the immune system and aging that cannot be ignored.

Athletic Performance Enhancer

CoQ10 Athletic performanceThree double blind human studies demonstrated an anti-fatigue effect in exercise with 300 milligrams CoQ10 daily, specifically in long periods of exercise, after 210 minutes
To quote one self monitor:

Within about 3 weeks i went from walking at a normal pace for several blocks to running the same distance with no problems. My cardio has been something that has always let me down. As a martial artist it really helped with my cardio endurance immensely. going from being worn out from a warm up to wanting to do ALOT more training at the end of every class.


antioxidant CoQ10UBIQUINONE-10 AS AN ANTIOXIDANT published in 2008 in the Journal of Food Biochemistry

This study was done to determine if the oxidized form of coenzyme Q, ubiquinone, was capable of acting as an antioxidant. In this study, it is shown that it can function in this manner.


CoQ10 DepressionTo quote a 2009 Belgian study of 35 patients suffering from treatment resistant depression:

The results show that lower CoQ10 plays a role in the pathophysiology of depression


CoQ10 FatigueCommon sense would suggest that something which empowers the mitrochondrial process would be profoundly helpful to those suffering from low energy levesl. A 2005 human study of 13 patients confirmed this:

Subjects with unexplained chronic fatigue of unknown etiology for at least 6 months were recruited... The percentage of users who found a treatment helpful was greatest for coenzyme Q10 [was] 69%...

Originally it was discovered by the University of Wisconsin in a series of experiments isolating it from beef hearts in 1957 by Dr Fred Crane.


CoQ10 comes from a variety of animal sources:

  • Beef
  • Liver
  • Pork and Chicken Heart
  • Sardines
  • Herring
  • Mackeral

Along with

  • Butter
  • extra virgin Olive Oil

Supplemental CoQ10 can be extracted from food sources, but it is prohibitively expensive to do so and the majority of CoQ10 supplements are synthesized from bacteria in a laboratory:

Given the dietary problems western society faces at large, it is no surprise that CoQ10 deficiency is rampant and associated with the following diseases

  • Heart attack related fibromyalgia (post-myocardial infarction)
  • Depression
  • Migraines
  • Prader-Willi syndrome
  • Male infertility
  • Peyronie's disease
  • Parkinson's disease

According to a 2009 paper published in Journal of Neuropsychiatric Disease and Treatment:

(CoQ10) is an essential cofactor in the mitochondrial respiratory chain... Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress.

Mitochondrial Nootropic

Head Strong bookHead Strong by Dave Asprey makes the case that optimizing your Mitochondria is the ultimate performance enhancing Biohack because your Mitochondria are the fundamental energy generation mechanism that underlie everything else. From the book:

You make this antioxidant in your mitochondrial membranes. Its job is to carry electrons into the mitochondrial inner membrane, where it is oxidized to create energy and protect against oxidative stress. In other words, it helps your mitochondria produce energy more efficiently while protecting against the oxidative stress that energy production causes. (p. 259)


Creatine is a synchronous agent in combination for a potent neuroprotective effect:

(CoQ10) and creatine are promising agents for neuroprotection in neurodegenerative diseases via their effects on improving mitochondrial function and cellular bioenergetics and their properties as antioxidants.

L-Carnitine, a synergistic intermediate with CoQ10 in mitochondrial function.
The CoQ10 process in the body requires Tyrosine and Vitamin B6.
Alpha-Lipoic Acid
Grape Seed Extract

Nootropic Ingredients


Unfair Advantage (from $50)
Ubiquinol CoQ10 with Enhanced Mitochondrial
High-Absorption CoQ10


Minding your mitochondria: Dr. Terry Wahls at TEDxIowaCity
Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ | Life Extension
CoQ10 as a Nootropic: Biohacking the Mitochondria for Inspiration and Immortality

CoQ10 Supplements

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