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Nootropics & Smart Drugs

Scientific Studies

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Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva.
Since heavy physical exercise increases the content of nitric oxide and cortisol in blood and saliva, standardized extracts of the adaptogen herbal drugs Schizandra chinensis and Bryonia alba roots were applied to several groups of athletes in a placebo controlled double blind study. In the beginning of a test with athletes Schizandra chinensis and Bryonia alba extracts increased the...
 
Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.
AIM: To study the effects of huperzine A (HupA) on neuritogenic activity and the expression of nerve growth factor (NGF).
 
Effects of l-theanine on attention and reaction time response
Previous human studies revealed that l-theanine influences brain function. The current study was designed to evaluate the affect of l-theanine (Suntheanine®) on attention and reaction time response in 18 normal healthy University student volunteers. In accordance with preliminary analysis of the manifest anxiety scale (MAS), the subjects were divided into two groups referred to as high anxiety propensity group...
 
Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors
To study the effects of acute and repeated injections of nootropics and to learn how glutamate receptors might be involved in their mediation, the frequency spectra of cortical and hippocampal electroencephalogram (EEG) were analyzed in non-narcotized rats subcutaneously injected repeatedly with Piracetam (400mg/kg) or its analogue, Noopept (0.2mg/kg), after intracerebroventricular infusions of saline (5 μl) or the antagonists of...
 
Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.
AbstractIn vitro preincubation of brain membranes of aged mice with piracetam (0.1-1.0 mmol/L) enhanced membrane fluidity, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). Piracetam had similar in vitro effects on brain membranes of aged rats and humans, but it did not alter brain membrane fluidity in young mice. Chronic treatment of young and aged...
 
Effects of sulbutiamine on psycho-behavioral inhibition in major depressive episodes
AbstractPsycho-behavioural inhibition is characteristic of major depressive disorder and frequently recedes after the other depressive symptoms. This may induce an important psychosocial impairment which could be a risk factor for relapse. METHODS:The aim of this eight weeks, multicentric, randomized, double blind, placebo controlled trial was to assess the efficacy and safety of sulbutiamine (Arcalion) [600 mg p.d.]...
 
Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease
AbstractThe efficacy of the inhibitors of acetylcholinesterase in Alzheimer's Disease (AD) is moderated and some patients do not respond to these treatments. Sulbutiamine potentializes cholinergic and glutamatergic transmissions, mainly in hippocampus and prefrontal cortex. This multicentric, randomized and double-blind trial evaluates the effects of the association of sulbutiamine to an anticholinesterasic drug in cognitive functions in patients with AD...
 
Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study.
The pharmacological effects of the neuroprotective drug vinpocetine, administered intravenously in a 14-day long treatment regime, on the cerebral blood flow and cerebral glucose metabolism in chronic ischemic stroke patients (n=13) were studied with positron emission tomography in a double-blind design. The regional and global cerebral metabolic rates of glucose (CMRglc) and cerebral blood flow (CBF) as well as...
 
Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states.
The psychophysiological model of provoking different emotional states by watching film excerpts with various emotional contents was used to characterize drug action in 80 subjects (male/female=50%) with threshold emotional disturbance within a randomized, group-parallel, double-blind, placebo-controlled study. Analyzing the brain's electrical reaction during presentation of 5 videoclips of 7 min duration followed by 3 minutes pause revealed a content...
 
Efficiency of noophen in heroin addiction
Abstract24 patients with heroin addiction have been observed with the purpose to assess cognitive and neurosis-like disorders during the treatment with Noofen. The methods of research included clinical-psychopathological examination. The course therapy with Noofen reduced intensity of memory and attention disorders and improved general cognitive status of the patients. The therapy with Noofen has not increased a pathological drive...
 
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