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A randomized, double-blind, crossover trial of modafinil on mood

 
A randomized, double-blind, crossover trial of modafinil on mood

Abstract
Modafinil, a medication for the excessive sleepiness associated with narcolepsy, has been hypothesized to improve not just alertness but mood as well. The purpose of this study was to determine how treatment with modafinil affects mood in healthy volunteers. Normal healthy volunteers (n = 12, 10 men and 2 women; 30-44 years) underwent a 3-day, counterbalanced, randomized, crossover, inpatient trial of modafinil (400 mg daily) versus placebo with 4-day washout period between 2 treatments. Mood was assessed daily using both the Positive and Negative Affect Schedule and a general mood scale, which consisted of 10 bipolar adjective ratings based on a severity scale ranging from 1 to 10. Modafinil increased general mood and Negative Affect scales relative to placebo and had a significant effect on Positive Affect scales. These results suggest that modafinil may have general mood-elevating effects accompanied by increased negative affect (anxiety). The findings may have implications for clinical practice, in particular for the adjunctive use of modafinil in treatment-resistant depression.

Scientific Studies & Papers

Author of Study or Paper
Taneja I, Haman K, Shelton RC, Robertson D.
Source
Department of Pharmacology, Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN
Date Published
2007 in Journal of clinical psychopharmacology
About Study
  • Double Blind
  • Randomized
  • Human Study
  • Crossover
Number of Human Participants
12

Modafinil Sources

Modafinil by Modup  
Modafinil by AfinilExpress  
ModafinilBuyOnline.com  
ModaPharma.com  
Modafinil by ModafinilStar  

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