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Nootropics & Smart Drugs



By Jonathan Roseland  Connect    

Renowned as a tool for preventing cognitive decline, promoting memory and enhanced powers of logic that would make a Vulcan jealous.

Similar to Aniracetam, Oxiracetam, is an Ampakine that modulates the AMPA Receptor and promotes long term potentiation (LTP) according to a paper published in the British Journal of Pharmacology. Long term potentiation, is the foundation of memory, it's the process of signal enhancement on a microscopic level between neurons. We rely on it for personal development, learning new skill sets, and much more. It increases the nuerotransmitters endogenous glutamate and D-Aspartic Acid which enable better signaling between hippocampal brain cells, according to an Italian study. To quote another Italian study:
"Taken collectively, these results support the view that nootropic drugs act as positive modulators of AMPA-sensitive glutamate receptors in neurons."

logicThe racetam is reported anecdotally all over the Internet to aid logic, mathematic or spatial intelligence intensive tasks. To quote an insightful review of the smart drug:
"Sometimes ideas and concepts will come to mind seemingly void of emotion, meaning it is (apparently) easier to get to the point of the matter. This is a difficult concept to articulate. I can see a potential advantage in those cases in where emotional bias might otherwise cloud one's logical reasoning process."

Oxiracetam is chemistry's gift to those suffering from cognitive decline, specifically dementia.dementia Dementia is a saddening age-related condition, it's most noted for it's crippling impact on day to day quality of life along with robbing those afflicted of their memories. Both forming new memories (like remembering meetings) and recalling long term memories of life experiences. The good news is that it's preventable and treatable. Improvements in the following dimensions result from Oxiracetam:

A double blind Italian study of 272 people suffering from Dementia conducted by the University of Torino showed that those taking Oxiracetam had significant improvements in their cognitive decline as measured by the Newcastle Memory, Information and Concentration Scale. To quote the study:
"A multicentre, double-blind, between-patient study was carried out to evaluate the efficacy and tolerability of oxiracetam... A significantly different effect in favor of oxiracetam was observed on the quality of life scale, and confirmed by significant differences in some neuropsychological tests"

Participants of a Danish study scored higher on tests for attention, logic, spatial orientation and concentration. The study was on those with varying moderate degrees of dementia or ADHD at dosages of 800 - 2400 Milligrams daily. Oxiracetam is demonstrated as more effective than Piracetam according to V. Gallai et al.

hippocampallyIncreases spacial learning and hippocampally-mediated learning by improving a protein related processes in brain membranes. This is part of Oxiracetam's purported mechanism of action, according to a study by the Institute for Behavioural Genetics at the University of Colorado:
"...performance was also improved in contextual learning as determined by the fear conditioning task. The increase in spatial learning performance was correlated to an increase in membrane-bound PKC."

GABAAlso a GABA analogue, GABA is an important neurotransmitter to the function of the central nervous system, it regulates excitability in our nervous systems. Which has positive implications for Nuerodegenerative disorders according to a 2010 Polish study, to quote the study:
"To resolve this problem, GABA analogues are being designed. Over recent years, there has been increasing interest in the synthesis and pharmacological effect of new GABA derivatives, which can be considered as potent drugs in the treatment of neurodegenerative disorders."

Oxiracetam has a positive effect on acetylcholine signaling but does not increase the baseline of acetylcholine.acetylcholine Acetylcholine or ACH, is a chief nuerotransmitter of the mind and body, it's a communicator between our muscles and brains. It is used by the central nervous system (CNS), autonomic nervous system (ANS), peripheral nervous system (PNS), and the sole neurotransmitter used in the somatic nervous system's motor division. According to a study published in Clinical Neuropharmacology, the presence of Oxiracetam increases the utilization of acetylcholine by up to 31%.

EEG SleepBased upon EEG readings done by a University of Paris study, Oxiracetam does not hurt the quality of sleep but it does cause sleep latency. So it may take you longer to fall asleep if you take the smart drug later in the day. No effects of lucid dreaming are reported in scientific sources.

musicAnecdotally, it enhances the experience of music... To quote a Longecity review:
"I must agree that Oxiracetam enhances sound like nothing else. Those waves can almost be tasted on the tongue, inside the brain... more real than real..."

Good news, it doesn't taste as bad as the other Racetams, it's reported frequently as being somewhat sweet.

Like other Racetams, it is creating synthetically in a lab. It differs chemically from Piracetam because of a single hydroxyl.

Although you can find +90 studies and scientific papers specifically on Oxiracetam on Pubmed, it is sometimes criticized as a smart drug for having a shortage of human studies.

Why Racetams?

Piracetam Studies

Other Racetams

Nootropic Ingredients



Since it promotes Acetylcholine but is not a building block of the important neurotransmitter, it's great idea to take with an Acetylcholine precursor like Alpha GPC or a Choline supplement.

Side Effects:

Like the other Racatams Oxiracetam is a high return, very low risk tool for a Limitless Mind. The common complaint with Racatams is the headache if you do to much, There are some anecdotal reports of irritation while dosed on it, the theory on this is that it is because the greater clarity makes one more aware of negative emotions.



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Oxiracetam as a Nootropic: Benefits, Sources, Dosage, Side effects and Supplements


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Oxiracetam Sources

Oxiracetam by Intellimeds  

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