Pyrroloquinoline Quinone (PQQ)
| By Jonathan Roseland |
I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health. Affiliate links in this article support Limitless Mindset - spend over $150 and you'll be eligible to join the Limitless Mindset Secret Society.
On the extraterrestrial origin of PQQ
From Dr. Lee Know's recent book
From an evolutionary perspective , current evidence suggests PQQ is a component of interstellar dust , and since it’s been postulated that strong redox catalysts were required to trigger the earliest chemical evolutionary steps , the extraterrestrial origin of PQQ raises the question of its evolutionary importance to simpler life forms . This theory is especially interesting when you consider PQQ’s wide range of chemical properties , such as a redox catalyst and the ability to modify amino acids ( e.g . , oxidative deamination reactions ) . Could PQQ be our common point of origin with life in other areas of the galaxy ? (2290-2294)
Stimulates the Growth of Mitochondria
Traditionally , it was believed that generating new mitochondria ( mitochondrial biogenesis ) could only occur as a result of strenuous exercise or extreme calorie restriction , which is why research on PQQ ( pyrroloquinoline quinone ) is so exciting . Early in 2010 , researchers found PQQ not only protected mitochondria from oxidative damage , it also stimulated the growth of new mitochondria ! (2274-2277)
PQQ as a Nootropic
Related to this is cognitive function . As we discussed , the brain uses an incredible amount of energy , and it is utterly dependent on the mitochondria for fuel . A double - blind , randomized , placebo - controlled human clinical trial found that 20 milligrams of oral PQQ taken daily improved short - term memory , attention and concentration , information identification , and processing ability in healthy adults . Effects were greatly enhanced with the addition of CoQ10 supplementation , which makes sense because Complex I transfers its electrons to CoQ10 in the ETC .(2334-2338)
Vs Cancer
PQQ can also reduce cancer risk by mechanisms separate from mitochondrial biogenesis . For example , PQQ has been shown to affect the activity of ras ( a gene that can potentially cause cancers ) (2304-2306)
A B Vitamin
In 2003 , Japanese scientists made a significant announcement in the prestigious journal Nature : They had discovered direct molecular evidence that PQQ was in fact a previously unidentified B vitamin . A vitamin , by definition , is a compound that human bodies can’t make ( we must get it from dietary sources ) and is an absolute necessity to carry out at least one essential biochemical function . (2315-2318)
Downloadable PQQ?
You may be interested in taking it as an infoceutical - a non-pharmacological, side-effect-free version of the supplement that takes advantage of the phenomenon of water memory - which is imprinted on water via quantum collocation and electromagnetism using this device...
Infocueticals typically have 1/3 or half the effect of the actual medicine being imprinted. If you're skeptical of Infopathy that's understandable, it's a game-changing application of a little-known scientific phenomenon. But I'd urge you to evaluate the scientific evidence (presented in my biohacker review) that downloadable medicine is no longer science fiction...
Mechanism of Action
Ben Greenfield writes in his anti-aging manifesto, Boundless...
Pyrroloquinoline quinone (PQQ) is an antioxidant that’s involved in redox reactions, which change the oxidation states of atoms, in living organisms ranging from bacteria to human beings. More than 175 published studies have shown that it has wide-ranging benefits for memory, general cognition, mood, and mental processing power, making it a popular ingredient in many nootropics. PQQ’s benefits also include increased mitochondrial density, defense against oxidative stress, improved learning and memory ability, and reduced inflammation.
Dietary Souce: Chocolate
More research should be done to clarify PQQ’s contribution to the health benefits of chocolate , but in the meantime , moderate consumption of dark chocolate would seem to be a great way to treat yourself (2347-2348)
Cofactors
Using PQQ in combination with CoQ10 seems to synergistically increase their potency, so I recommend taking a combination supplement that includes both... (p.965)
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