Pure Nootropics

Double Wood Supplements in the USA offers COA-verified Citicoline capsuled, the most convenient form.

Centrophenoxine is a cholinergic compound which is a derivative of Dimethylaminoethanol (DMAE) and pCA (para-chlorophenoxyacetic acid) (1). As a cholinergic, it increases levels of acetylcholine in the brain.

May increase alertness and support memory (ref)*
May increase concentration and focus (ref)*

Centrophenoxine is a subject of interest in the medical community but thus far, the amount of clinical trials in humans is not plentiful. Some of these human studies are referenced above.

The following references are examples of dynamics associated with Centrophenoxine through the animal model and may not be representative of the effects in the human body:

Promotes antioxidant activity (ref)(ref)*
Supports information recall in elderly animal subjects (ref)*
May decrease lipofuscin (pigments related to aging) (ref)*
Supports RNA synthesis (ref)*

About

Centrophenoxine is prescribed in some countries under the brand name “Lucidril” to help combat Alzheimer’s. It is synthesized from DMAE. DMAE is a natural chemical that has been shown to improve areas of cognition and mood. DMAE’s exact method of action is slightly disputed. Some see it as a precursor to Acetylcholine but others contest this as choline molecules broken down from DMAE are not believed to cross the blood-brain-barrier efficiently.

Coluracetam is a nootropic from the racetam family. It works as a high affinity choline uptake enhancer and was originally developed for use with Alzheimers disorder although it did not reach endpoints in clinical trials. Another clinical trial, carried out by BrainCells Inc have suggested that it would be a potential medication for depression and anxiety [1]. By increasing choline uptake and synthesizing Acetylcholine it is thought to enhance cognition, improve memory and help rational decision making.

Introducing Coluracetam, available in both 10mg capsules and tablets. Elevate your cognitive performance with our premium supplement.

Enhances memory and learning
Promotes focus and concentration
Supports cognitive clarity
Aids in mental alertness
Assists in mood regulation

Biohacker Review: The caviar of antidepressants to vanquish seasonal affective disorder

I filmed my video about this drug in front of the Parliament Building in Bucharest, Romania. As you can see it's a very gray, brooding building, in a part of the world that this time of the year is also very gray and brooding during winter.

For the past four months or so I've been living in Eastern Europe, which is a nicer part of the world than you would guess from the headlines but during this season it's kind of a global hotspot for SAD (seasonal affective disorder) which  -  unless you live somewhere you need to worry about coconuts falling on your head  -  is something you've probably experienced. During the winter season, there's a whole lot less sunlight, the days are shorter, you spend more time indoors, you sleep more, you might gain some weight, you're less likely to go to the gym, or hang out with friends, and a lot of people suffer from mild depression as a result for a couple of months out of the year.

So there are some holistic ways to beat SAD, like setting up a home gym, following a strict diet, or even installing special lights in your bedroom that signal to your neurobiology that it's summertime. However, I'm a digital nomad and none of these options work great for me. For me, Coluracetam has been an irreplaceable Biohack for beating SAD. 

It's not a hardcore focus drug like Modafinil, nor does it give me a bunch of energy and pep like caffeine or Piracetam. What it does is just add a subtle and underlying positivity to my mood. There's a noticeable difference on it and off it, especially in this dreadfully gloomy part of the world.

It's a quintessential antidepressant

Some comedian made a joke about what happens if you take antidepressants when you aren't actually depressed… Do you just become more awesome? In the case of Coluracetam, not so much, I would say it improves my mood by 25% - 75%.

One day I did about 20 milligrams 15 minutes before my afternoon meditation session, during the meditation I can appreciate the optimistic mood it puts me into. This sensation lasted about four hours.

It's not great for mood permeability, I did it a few times near the end of my workday when I was in zombie borg drone mode and headed to do something social. It does make me slightly more optimistic which is helpful but it didn't help me get in a carefree social mood like Phenibut, Kratom, or even meditation does. It won't be my go-to social smart drug…

Nootropics can be enablers of Nihilism

While one day I started watching documentaries about ISIS and the European migrant crisis, and I was drawn into the rabbit hole of Nihilism.
The healthy thing to do would be to not watch the depressing content, but I found myself using the antidepressant as an excuse to indulge my Nihilism.

Experiential

I tried Coluracetam for the first time in the amount of about 20 milligrams when I was doing a walking tour of Berlin (got a few touristy photos attached). Despite walking around an amazing city center on a beautiful summer day I didn't quite experience this often-praised effect of the outdoor world seeming more vivid.

Pure Nootropics - Page 2 - Limitless Mindset

At the Spree river after a little chocolate shopping...

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I definitely was NOT there hitting on girls at the university coffee shop...

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One of the most profound places I've ever been...

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At Checkpoint Charlie

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Me, touring Berlin on Coluracetam

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YET another church...

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Stacking

A Youtube commenter suggested stacking Coluracetam with L-Theanine, which I tried and it's a pretty good stack, especially in combination with some delicious Bulletproof-style coffee. The creative mindset that L-Theanine puts me in is nicely complemented by the optimism that Coluracetam stimulates - this has become my go-to stack since I ran out of Piracetam.
Speaking of coffee, anecdotally Coluracetam has this cool effect of reversing caffeine tolerance. I, unfortunately, did not experience this, at least not noticeably. Another consistent way to reverse caffeine tolerance is just to stop consuming caffeine for about 10 days and your caffeine tolerance will almost completely go away. And after consuming just a single cup of coffee you will again feel like a Greek god consuming ambrosia in the fields of Elysium. Coluracetam did not have the same effect for me.

It has a rocky, clumpy consistency that reminds me of cocaine  -  the tiny rocks feel like boulders under my tongue. You may need to break it up before consumption. I've been taking it sublingually because it's so damn expensive that I don't want to waste a single granule of it. Its taste is not pleasant and it kind of lingers on your palette, I don't recommend taking it before a meal. It doesn't taste great but it's not as bad as some drugs I've tried.

Scienceguy on Longecity suggested it potentiates Oxiracetam, I've taken it now a couple of times with Caballo which has Oxiracetam but I'm not sure if I've experienced this yet…
One day I was operating on about four hours of sleep, so I was somewhat sleep-deprived and kept slipping back into an unfocused funk. I took Coluracetam around 1 PM and 4 PM and there was a disappointing absence of an effect.

I wish I could rate Coluracetam higher, but I'm deducting two stars because it's just not a great value, there are plenty of Nootropics that gram for gram, cost a 3rd or 4th of Coluracetam and have just as helpful effect on mood, focus, and memory. For mere economics, I wouldn't reorder it.

What Is DMAE-Bitartrate?

DMAE-Bitartrate (dimethylaminoethanol bitartrate) is a chemical naturally found in the body that helps control neurotransmitters in the brain. Fatty fish, such as salmon, anchovies, and sardines, are rich sources of DMAE.

Pharma-grade, COA-verified Fasoracetam - manufactured and quality tested in America.

Pure Nootropics Huperzine A is a natural nootropic derived from the Chinese club moss Huperzia serrata, which supports a healthy memory and cognition and helps increase levels of acetylcholine.

Pure Nootropics Krill Oil provides cognitive and heart benefits and helps with joint pain: A great source of Omega 3’s (DHA & EPA) and Astaxanthin.

• Cognitive: Shown to increase cognitive function in elderly men (reference)
• Cognitive: Increased cognitive function and anti-depressant like effects in healthy humans (ref), and rats (ref)
• Heart: Beneficial effects for people with cardiovascular disease and healthy individuals (ref)
• Joint Health: Inhibits inflammation and reduces arthritic symptoms (ref)
• Higher bioavailability (more easily absorbed by the body) than Fish Oil. (ref)

What is L-Theanine?
First discovered as a constituent of green tea leaves (Camellia sinensis) in 1949, L-Theanine is an amino acid analogue of the proteinogenic amino acids L-glutamate and L-glutamine. L-Theanine is considered a nondietary amino acid, not unlike L-Ornithine or L-Citrulline. L-Theanine is primarily known for its ability to promote relaxation without causing sleep and is often paired with Caffeine. It is thought that L-Theanine helps balance the negative effects of Caffeine that some people experience. Together, L-theanine and Caffeine are considered one of the most commonly used and popular nootropic stack options that may promote faster reaction time, numeric working memory reaction time and improved sentence verification accuracy.

L-Theanine Benefits and Uses
L-Theanine benefits and uses may include:

Promotes relaxation
Support healthy sleep cycles
Support healthy stress levels
Promote feelings of well-being
Support cognitive function and focus
Synergistic effects with Caffeine

L-Theanine Studies
L-Theanine may have positive mood-boosting effects as scientists have discovered that it changes levels of amino acids affecting serotonin and other neurotransmitters in the brain. L-Theanine may also help suppress glucocorticoids. Glucocorticoids are stress hormones that can have a negative effect on mood, memory and learning. L-Theanine may act as a glutamate antagonist and, in turn, balance the harmful effects of high glucocorticoid levels. This also suggests that L-Theanine may be neuroprotective as well.

Additionally, L-Theanine may promote better sleep. One Japanese human study where participants were given a daily L-Theanine supplement concluded that L-Theanine did not induce sleep or make them sleep longer - but rather that it improved sleep quality. Documented participant responses claimed that exhaustion recovery and feelings of being refreshed were enhanced by L-Theanine.

L-Theanine supplementation has been studied for its potential ability to reduce mental and physical stress, improve cognition, and boost mood and cognitive performance. It is also reported to promote alpha wave production in the brain. One study conducted by Unilever was able to confirm that even small amounts of L-Theanine were able to promote alpha wave production as indicated on an EEG (Electroencephalography).

L-Theanine Dosage
As a dietary supplement, take one 200mg L-Theanine capsule daily.

L-Theanine may be synergistic with Green Tea Extract.

Biohacker Review: L-Theanine gives my creative process wings to soar

If you are a creative type L-Theanine is worth your attention. Bloggers, authors, and especially ad copywriters should know that L-Theanine is a promoter of Catchyismismism - a word I invented, its definition:

Ad copy that is soaking wet with creative, articulate, and concise eloquent grammatical constructs which will grab your readers' attention like a lover.