Cortexin

Cortexin is an anti-aging Nootropic comprised of over 35 different vitamins, amino acids, and essential minerals that you inject intramuscularly.

Like Cerebrolysin, Cortexin is made up of various amino acids and Neuropeptides. What makes it distinct from Cerebrolysin is that it has a lot more peptide fractions than amino acids. It's also important to note that Cerebrolysin comes exclusively from pig brains, whereas Cortexin is extracted from the cerebral cortex of young cattle and pigs. But to be honest, Cortexin is not likely the smart drug for you, I'll explain why...

Scientific Research
An Injectable Adaptogen
Gabaergic
Mechanism of Action
Ingredients
Experiential
Cofactors
Sources
Usage & Dosage
Side Effects
Risk Grade
Vs Cerebrolysin
Conclusion
Cortexin Videos

 Scientific Research

There are 19 notable clinical trials done with Cortexin that yielded meaningful human research.

Probably the best study done on Cortexin was a double-blind, placebo-controlled multi-center trial that included 270 patients suffering from ischemic stroke.

High efficacy and safety of cortexin in the complex treatment of patients with [ischemic stroke] has been shown...
The results were confirmed by the pharmacoeconomic analysis of treatment tactics based on the estimation of "net monetary benefit"...
Cortexin is recommended for treatment and rehabilitation of patients with [ischemic stroke].

The beneficial effects of Cortexin were observed after just a 10-day course of treatment.

The most recent study was done in 2014 in Russia and evaluated Cortexin's effect on those suffering from epilepsy. The researchers concluded

There were the significant decrease in the frequency of seizures and the absence of failure of remission, the positive dynamics of electroencephalographic pattern as well as stopping of such symptoms as headache, non-systemic vertigo, asthenia, cognitive impairment, anxiety and depression, arterial hypertension.

Its applications in treating conditions that children are suffering from have also been studied. A 2012 study combined Cortexin with microcurrent reflexotherapy, massage, and very simple gymnastics

The objective of the present study was to estimate the therapeutic efficacy of the combined treatment of infantile cerebral palsy by means of microcurrent reflexotherapy... in combination with the neuroprotector cortexin.

The study which totaled 69 children found that 60% of the children given the tri-part treatment developed the ability to walk unassisted.
Another study of 60 children aged 7-12 years old found that it improved the memory disorders of 86% of the children. Hey, that's pretty good!

Another study compared the treatment of Cortexin to those suffering from chronic alcohol encephalopathy and polyneuropathy.

• Alcohol encephalopathy is a liver disease that results from a thiamine deficiency, it's also referred to as Wernicke–Korsakoff syndrome.
• Polyneuropathy is a disease with a deleterious effect on peripheral nerves on opposite sides of the body. So it would cause pain, weakness, or numbness in both your left and right elbows.

The study concluded

Cortexin had the positive effect on clinical symptoms, [Encephalography] and [electroneuromyography].

Like a lot of the Cortexin studies, it's not specific about the helpful effect of Cortexin for the patients.

 An Injectable Adaptogen

One study was done in Japan which compared Cortexin to Vinpotropil and Noopept which evaluated these Nootropics in a group of otherwise healthy young people. Interestingly, the study classifies Cortexin as an adaptogen which is a fascinating class of performance-enhancing drugs that modulate our stress response beneficially.

Cortexin is qualified as an adaptogen and actoprotector only for hypobaric hypoxia conditions...

Hypoxia is a medical condition associated with low air pressure and lack of oxygen. So this study would suggest that Cortexin increases oxygen utilization and is maybe a good drug for mountain climbers or athletes training at altitude. The study concludes

Therefore, all the drugs studied [vinpotropil and cortexin]... can be recommended as the agents producing activation, support and recovery of the physical and psychological efficiency under rapidly changing environment conditions.

A 2013 study looked at its effect on open-angle glaucoma. Unfortunately, the abstract translated into English does not give many specifics about the dosages or helpful effects.

 Gabaergic

Gaba is the devilish neurotransmitter that whispers in your ear...

Hey, why not? What's the worst thing that could happen?

Alcohol, Phenibut, and many antidepressants are Gabaergic, this is why they can be fun to party on. To people who genuinely suffer from anxiety and chronic stress, Gabaergics can be a godsend of tranquility and calm. Cortexin is a very subtle Gabaergic, so it won't exactly make you want to dance to techno but it will have a relaxing effect that can be very helpful to some.

 Mechanism of Action

A well-translated Russian review nicely synopsizes its mechanisms

Cortexin is a complex of polypeptide fractions penetrating the blood-brain barrier and affecting nervous cells. Cortexin has a neuroprotective effect and reduces toxic impact of psychotropic agents. Due to its antioxidative action Cortexin inhibits oxidative stress. The drug improves the bioelectrical activity of the brain. Mechanism of action of Cirtexin is determined by activation of neuronal peptides and neurotrophic cerebral factors; optimization of metabolic balance of excitatory and inhibitory amino acids, dopamine, serotonin; and GABAergic action.

Ingredients

Experiential

The consensus seems to be that it is subtle...

I would say the effects are more obvious during cycle than after cerebrolysin. It's more noticeable, I had better mood, especially during more demanding moments, when I had some sleep deficits . Both are nothing like stimulants, but rather subtle, natural nootropics with some anxiolytic effects.

One, not exactly enthusiastic, Biohacker reported

Anyway the first day of starting Cortexin i would say nothing changed in terms of how i was feeling, IE mixed feelings. Apart fromt the normal, subtle clarity... plus as i said above the feeling of being overloaded, like maybe i had brain fog and also the normal clarity at the same time...

Another Biohacker reported

[I] Hate [gabaergics]... taking Cortexin I hardly even gave a damn about anything, I could definitely feel enhanced focus at work etc, but I literally didn't give a shit about anything at all, which would have been counter-productive in the long run.

 Cofactors

• Some Biohackers combine it with Cerebrolysin
• Some have suggested stacking it with IGF LR3, however, there are some well-reasoned objections to this. Probably not a good idea.

 Sources

RUPharma, based in Moscow offers branded, patented, pharmaceutical-grade Cortexin - I do recommend that you use cryptocurrency to order it from them if you decide to use it.

Cortexin by RUPHARMA

Category: Nootropics & Anti-Aging

Downloadable Brain-derived proteolytic peptides?

You may be interested in taking it as an infoceutical - a non-pharmacological, side-effect-free version of the supplement that takes advantage of the phenomenon of water memory - which is imprinted on water via quantum collocation and electromagnetism using this device...

IC Pad by Infopathy

 

4.3

Category: Mind Hardware

Infocueticals typically have 1/3 or half the effect of the actual medicine being imprinted. If you're skeptical of Infopathy that's understandable, it's a game-changing application of a little-known scientific phenomenon. But I'd urge you to evaluate the scientific evidence (presented in my biohacker review) that downloadable medicine is no longer science fiction...

 Usage & Dosage

Many of the clinical trials and Biohacker reports suggest 10-day dosing cycles.
Injection
The best way to take Cortexin is to inject it intramuscularly, so in your thigh, butt, or major muscle. It's recommended that you have a medical professional show you how or very carefully follow some of the tutorials online about how to safely perform injections.

 Side Effects

• The 10-day study treating alcoholics concluded: The drug was well-tolerated, no side-effects were observed.
• Several users have also reported the rather benign yet undesirable side effect of muscle fasciculations or small muscle spasms.
• There are also some reports of nasty side effects when taking it nasally.

 Risk Grade: C

• It's an injectable drug, so it bypasses some of the natural filter mechanisms of the body and clumsy users should be careful with needles.

• It's been studied extensively in Russian but lacks international studies that have been peer-reviewed and published in English for the public in open journals.

• It doesn't deserve higher than a C grade. It's not a low-risk drug.

 Vs Cerebrolysin

• The first thing that a frugal Biohacker will notice is that Cortexin is quite a bit cheaper than Cerebrolysin.
• From a review out of St. Petersburg comparing the two: Both drugs exhibited moderate psychoactivating effect, the effects cortexin were more pronounced compared to those of cerebrolysin in all tests.
• Overwhelmingly the user reports indicate that it's a lesser smart drug than Cerebrolysin.

Ultimately, though I think this is a case where you get what you paying for. I rigorously evaluated the risk profile of Cerebrolysin, based upon a wealth of data, and I think it's a better option for almost everyone.

CEREBROLYSIN®

Category: Nootropics & Anti-Aging

 Conclusion

Cortexin was created in 1986 by a Russian military medical academy so it's a relatively younger drug compared with the Racetams, for example, but it's failed to attract much attention from the international anti-aging research establishment or DIY self-quantifyers.
The Japanese study that evaluated it in healthy young people as a performance-enhancing adaptogen is interesting, but there are a lot of much safer and proven Adaptogens out there that work great and don't require jabbing yourself with a needle!
In my view, Cortexin is for those who need it to treat a serious illness or Biohackers with higher risk tolerance and demand for pharmacological novelty.
I would not give it to my own babushka.