By Jonathan Roseland

I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinkingYou should consult a professional about any serious decisions that you might make about your health. Affiliate links in this article support Limitless Mindset - spend over $150 and you'll be eligible to join the Limitless Mindset Secret Society.

Creatine is one of the most well-known health supplements. It's often caricatured as something just for gym bros because it helps them build muscle but actually, it's a veritable Mitochondrial Nootropic.

Mechanism of Action

Mitochondria and the Future of MedicineFrom Dr. Lee Know's recent book

Creatine is directly related to ATP . When a cell uses ATP , it loses a phosphate molecule and becomes ADP , which must be converted back to ATP for useful energy cycling . Because creatine is stored in the body as creatine phosphate , it can donate a phosphate molecule to ADP to regenerate ATP . This process is very speedy and is the main source of cellular energy production at the start of high - intensity anaerobic activity ( such as a 100 - meter sprint or lifting heavy weights ) . Having a large pool of creatine phosphate means this fast pathway of ATP regeneration can be sustained longer , which is exactly why creatine has been so beneficial for athletes .(2640-2645)

Creatine and the Brain

Because the brain and nervous system require such high amounts of energy , it’s logical to assume the neurological system can benefit greatly from creatine — and this is being corroborated by clinical research . A growing number of studies have found that creatine can protect the brain from neurotoxic agents and certain forms of brain injury . (2650-2652)

 Mitochondrial Nootropic

Head Strong bookHead Strong by Dave Asprey makes the case that optimizing your Mitochondria is the ultimate performance enhancing Biohack because your Mitochondria are the fundamental energy generation mechanism that underlie everything else. From the book:

Creatine has been a workout staple for decades, but the guys in the weight room probably don’t realize that creatine works by increasing ATP production in your mitochondria. This is what gives your muscles an extra boost of energy. Creatine also benefits your brain. In one study, creatine supplements caused a significant increase in working memory and intelligence. 
(p. 263) 

On the two-week Head Strong program, I recommend the loading phase so that you can feel the creatine’s effects right away. If you do this, be sure to drink a lot of water. (p. 264)

A Muscle-Building Biohack

Boundless bookBen Greenfield in Boundless, breaks down why Creatine belongs in your bodybuilding armamentarium

With increases in exercise or muscle damage, your physiological need for creatine is increased. Research suggests that creatine supplementation can increase your muscles’ work capacity and power output while enhancing your lean body mass and physical endurance. Outside of the athletic population, creatine has been shown to reduce muscle breakdown and even to support cognitive function, especially in the elderly. Because creatine stores high-energy phosphate groups in the form of phosphocreatine, it releases energy to aid cellular function during stress. This effect causes strength increases after creatine supplementation and can also benefit the brain, bones, muscles, and liver. I recommend 5 g per day, preferably in one to three doses and mixed into warm water or another warm liquid to maximize absorption. (p.581)

Downloadable Creatine?

You may be interested in taking it as an infoceutical - a non-pharmacological, side-effect-free version of the supplement that takes advantage of the phenomenon of water memory - which is imprinted on water via quantum collocation and electromagnetism using this device...

Infocueticals typically have 1/3 or half the effect of the actual medicine being imprinted. If you're skeptical of Infopathy that's understandable, it's a game-changing application of a little-known scientific phenomenon. But I'd urge you to evaluate the scientific evidence (presented in my biohacker review) that downloadable medicine is no longer science fiction...

Usage and Dosage

Do a “loading phase” in which you take 20 g daily (four doses of 5 g) for a week, then 5 g daily to maintain after that.

Creatine gets into your muscles more effectively if you pair it with a tiny amount of glucose. You don’t need much, so I recommend taking it with a quarter of a teaspoon of raw honey. (p. 264) 


Biohacker (and large human) Thomas DeLauer suggests as Nootropic cofactors for a multiplied neurogenesis effect, Lion's Mane or Reishi mushroom.

Nootropic Ingredients


The "swiss army knife" of Mitochondrial support supplements ? Creatine Biohacker Overview & Review

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