Glutathione
| Ⓒ By Jonathan Roseland |
I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health. Affiliate links in this article support Limitless Mindset - spend over $150 and you'll be eligible to join the Limitless Mindset Secret Society.
The Master Anti-Aging Antioxidant
At the root of aging and disease is the molecular poop that your trillions of Mitochondria excrete. Free radicals, ions that bounce around wreaking molecular havoc, are an inevitable byproduct of the body's underlying ATP energy generation process. Glutathione is a very special antioxidant because it cleans up all that Mitochondrial poop in your cells. Our natural Glutathione levels decline as we age, which is aggravated by consuming alcohol, a bad diet, or even taking pharmaceutical antibiotics. When we get ill, viruses attack and blow up our cells which flings even more free radicals around our bodies. When we're sick our bodies badly need Glutathione reinforcements.
The science
There are over 800 scientific papers published drawing a connection between immune function Glutathione, including ten human clinical trials, from which we'll summarize the notable findings.
A master mitochondrial antioxidant
The Mitochondria manifesto, Head Strong by Dave Asprey, holds Glutathione in high regard...
Glutathione is a protective antioxidant that serves as mitochondria’s main line of defense against damage from oxidative stress, but sometimes your body doesn’t make enough of it. (p. 38)
Glutathione is your body’s master antioxidant in the liver, but it has an impact on every cell in your body. In fact, mitochondrial glutathione is called a “key survival antioxidant.” (p. 268)
Glutathione isn’t something you should take every single day—I skip one to two days a week because I don’t want my body to get used to it and then reduce its own production of natural glutathione. (p. 269)
Immune Enhancement via the Master Antioxidant
According to a 2015 placebo-controlled trial of 54 Americans, Glutathione beefs up the innate immune system as...
Natural killer cytotoxicity increased >twofold in the high-dose group versus placebo (P < 0.05) at 3 months.
Swedish and Italian studies noted that N-Acetyl-Cysteine, an upstream precursor of Glutathione promotes T-cell-mediated immunity in vitro and provides a significant attenuation of influenza and influenza-like episodes, especially in elderly high-risk individuals.
What people are reporting...
Boosts immune system - on Amazon
I think it is the best product for immune health and to keep you from getting sick!
The most noticeable benefits for me seem to healthier and less dry skin, and my immune system seems to stay very strong; I haven't been sick for longer than a day in over a year.
Great antioxidant! - on Amazon
Kept me from getting sick when my whole family was sharing a bad cold.
The most amazing supplement! - on Amazon
My holistic practitioner started me on this product, the best form sold is by this company, and I saw a dramatic change In my health. I am never sick! I sleep well, have energy and just healthier overall. I highly recommend this product!
Vs Hangovers
Glutathione is the master antioxidant, and it's a smart idea to supplement it if you're going to be doing a little (or a lot of) drinking. In a sense, you always have a mini-hangover as your body is depleting Glutathione all the time but alcohol is especially costly of your Glutathione stores.
- It's rocket fuel for your liver function. From a 2017 clinical trial, Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases...
- It's a powerful intercellular antioxidant. Glutathione as a molecule is very charitable with its electrons, thus blocking the oxidizing free radicals which the booze introduces from their rape and pillaging of your biology.
- It enhances immunity. As you may have experienced, alcohol retards immunity. If you've ever caught the flu or a cold in the chilly days following some holiday binge drinking you have only yourself to blame! Glutathione fortifies the immune system, from some German research The immune system works best if the lymphoid cells have a delicately balanced intermediate level of glutathione.
Take 100-300 milligrams during or after drinking.
Sources
Double Wood Supplements offers COA-verified pure S-Acetyl L-Glutathione, manufactured in the USA. Glutathione supplements are all the rage but most Glutathione is not highly orally bioavailable (nor is it cheap) so I suggest you choose the S-Acetyl version which is better absorbed.
Double Wood's customers praise it highly as boozing biohack, Juan reported:
I put it to the test by consuming alcoholic beverages [to] the point of intoxication (in a safe monitored environment) and then immediately took two capsules of the Acetyl L-Glutathione. Surprisingly the next morning my hangover was dramatically reduced. I then repeated the test a week later with the same amount of alcohol without the supplement and my hangover was very bad. I did this 4 more times and every time the hangover was almost nonexistent with the supplement vs not taking it.
From a verified customer review, Works great for detox and hangovers, on Amazon:
I take this with DHM when having a few cocktails. 1 of each before drinking, 1 of each before bed, and 1 of each first thing in the AM. Hangovers are either completely prevented or very short lived!
Why Liposomal Glutathione is also a good buy...
And contrary to what many nutritionists preach, significant amounts of orally administered glutathione can be absorbed intact if the glutathione is in liposomal form and is administered sublingually (under the tongue). Research has shown that taking glutathione sublingually results in better absorption than taking an encapsulated supplement. Liposomal glutathione administered sublingually can be very effective. Liposomes are small, fat-like droplets that are very similar to the membranes that encase your own cells. These membranes protect the contents of the liposomes from the process of digestion, so by taking glutathione that has been packaged into liposomes, you may be able to increase your absorption of orally administered glutathione. Liposomal oral glutathione seems to be taken up particularly well by the kidneys, heart, brain, lungs, skin, and small intestine. (p.550)
In Boundless, Ben Greenfield lists natural food sources...
To enhance natural GSH production, consume foods that contain GSH precursors, including milk thistle, quality whey protein, arugula, broccoli, cauliflower, and kale, and foods that support methylation, such as avocado, lentils, liver, garbanzo beans, Brazil nuts, grass-fed beef, and spinach. (p.134)
More ways to increase Glutathione
Here are more ways you can increase your glutathione: • Consume plenty of vitamin C, which helps maintain your body’s supply of glutathione. • Consume selenium-rich foods like beef, chicken, fish, cottage cheese (if you tolerate dairy well), and brown rice, as selenium is a glutathione cofactor. • If you don’t have allergies or sensitivities, supplement your diet with whey protein, which provides a complete amino acid profile. Glutathione synthesis requires the amino acids glutamine, cysteine, and glycine. • Consume turmeric: the curcumin it contains can help restore glutathione levels and improve the activity of glutathione enzymes.
Other sources
Downloadable Glutathione?
You may be interested in taking it as an infoceutical - a non-pharmacological, side-effect-free version of the supplement that takes advantage of the phenomenon of water memory - which is imprinted on water via quantum collocation and electromagnetism using this device...
Infocueticals typically have 1/3 or half the effect of the actual medicine being imprinted. If you're skeptical of Infopathy that's understandable, it's a game-changing application of a little-known scientific phenomenon. But I'd urge you to evaluate the scientific evidence (presented in my biohacker review) that downloadable medicine is no longer science fiction...
Usage and Dosage
Effective doses of glutathione range from 250 to 300 mg daily, generally taken over the period of two to three months to achieve adequate levels. (p.135)
Cofactors
Colostrum - Taking your Glutathione hacking to the next level demands the chelation of the heavy metal iron in the gut. Chelation comes from the Latin word, Chela which means Claw, so chelators claw stubborn toxins out of your body. Chelating supplements and foods are a smart idea for any biohacker, but Colostrum contains Lacto-Theron, a quintessential Glutathione cofactor.
Alpha Lipoic Acid - This is another formidable antioxidant that supports Glutathione. The ALA supplements should be refrigerated. Take 400 milligrams before drinking.
Finally...
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