Performance Enhancers

Biohacker Review: An Ultra Vacation

I took the two products with me on an 8-day vacation to the black sea seaside, Amino Code and Ultra Keto+MCTs. People tend to totally cheat on their diets while on vacation because they booze at night and then wake up hungover and binge on pizza, junk food, or snacks.

My significant other and I had a fabulous time in the sun.

Performance Enhancers - Limitless Mindset

On vacation in Primorsko

Life is good on the black sea coast

At Obzor beach

• We did a bit of cheating on our diet and drinking BUT not every day and taking the Keto boosters in the mornings we managed to resist the temptation to splurge on junk food in the morning.
• We stayed pretty active the whole time and did activities every day.
• I managed to read most of the book I brought.
• On vacation, we had quite vigorous sex at least twice a day - for 8 days! This is a pretty good male performance for me. This probably has more to do with my liberal usage of Horny Goat Weed though than the Keto boosters.
  
• A girl who is a kickboxing instructor issued me a bit of a video challenge, in response one morning I created this silly video of me practicing martial arts on the beach.

Biohacker Review: An Invigorating Military-Grade Mushroom

This adaptogenic mushroom has a very cool name, doesn't it?

As a Nootropic its effect is pretty subtle, I didn't note much of an uptick in cognition but it does make you more energetic. I used it before the gym several times resulting in some kickass workouts but my go-to pre-workout supplement will remain HMB and Creatine. The past few weekends, my project has been cleaning out a very messy old attic of a bunch of old dusty junk and furniture so I can transform it into my doomsday prepping storehouse. Cordyceps gave me a bit of extra physical energy to spend hours carry stuff down 5 flights of stairs to the dumpster.

It has a pleasant taste and texture. I enjoyed it in a hearty adaptogenic tea with Turkey Tail, Chaga, Schisandra, Eleuthero, Matcha, and a splash of Apple Cider Vinegar.

The immuno-fortifying effects are one of the main things that make it attractive to me, along with the other Adaptogens it kept me and Mrs. Roseland from getting sick during the chilly Eastern European winter here.

I took it in a moderate dosage of several hundred milligrams once daily, as a Nutraceutical you don't need to worry about being really precise in your daily dosing. I would dump about a half-teaspoon into my mug. I didn't notice a big difference in effect varying the dosage.

I wouldn't take Cordyceps daily forever, I would cycle it. in my interview with Ergogenic Biohacker Lucas Aoun, he explained that it stimulates thyroid hormones, taking it in excess chronically could result in hypothyroidism. But, he remains a big fan of it...

Cordyceps has been a long-term staple in my life for many years. It consistently improves my immune system, energy levels and workout tolerance. I find it can make me much more decisive, and also improves libido (no surprise here).

 Summary of Cordyceps Science

On Pubmed, you can find +500 scientific papers referencing Cordyceps Militaris and two clinical trials in the past 5 years. I'll summarize some of the recent interesting findings...

A 2019 study was done at the General Hospital of Daqing Oil Field which found it protected against kidney disease. I can just imagine how hard and dirty a job working in a Chinese oil field must be, so it speaks to the potent stoicism enabling properties of adaptogenic mushrooms.

Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway.

A Korean placebo-controlled study of 79 healthy men found it produced an uptick in immune activity.

Cordyceps militaris is a mushroom traditionally used for diverse pharmaceutical purposes in East Asia, including China, and has been found to be effective for enhancing immunity... C. militaris enhanced the NK cell activity and lymphocyte proliferation and partially increased Th1 cytokine secretion. Therefore, C. militaris is safe and effective for enhancing cell-mediated immunity of healthy male adults.

It also noted that no adverse side effects occurred.

Another recent Korean paper noted an anti-cancer effect, it induced apoptosis in cancer cells, which is great the problem with Iatrogenic mainstream cancer treatments are that they do so much damage to our bodies and organs while killing cancer cells.

These results suggest that C. militaris inhibited ovarian cancer cell proliferation, survival, and migration, possibly through the coordination between TNF-α/TNFR1 signaling and NF-κB activation. Taken together, our findings provide a new insight into a novel treatment strategy for ovarian cancer using C. militaris.

Purity is a concern with Nutraceuticals, especially mushrooms

Mushrooms tend to absorb the toxins in the environment around them, making many of the mushroom supplement that you might find possibly Iatrogenic - they may actually do you more harm than good. This is why I wouldn't buy any old Cordyceps that I found on store shelves or online, especially if it's cheap. I'd also prefer not to get my Cordyceps in a "multi-vitamin" stack that combines it with a bunch of other things unless they proved its purity with a certificate of analysis. I enthusiastically recommend Lost Empire Herbs as they have the highest standards in the industry for quality assurance and purity testing.

99.99% Pure High Performance Formula

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Biohacker Review: A notable uptick in gym performance

I've taken 1000 milligrams (two capsules) of HMB before workouts and I believe there is a notable uptick in my gym performance. I'm able to lift more, along with doing more pullups and pushups. I've been getting acquainted with some pre-workout supplements in the last few weeks. I've also tried Mildronate before workouts. It's hard for me to compare and contrast the two from my subjective experience because I'll admit that when it comes to my gym performance it's hard to tell the difference between pharmacologically enabled gains and me just being more aggressive or the placebo effect. There's not much subjective experience with HMB as there is with many Nootropics.

Mildronate modulates and improves the function of the heart which has a number of downstream performance-enhancing effects both for our physical and mental capacities.

Meldonium, or Mildronate, is prescribed to treat “different heart and vascular diseases,” according to the Latvian manufacturing company’s website, though it also notes that the drug can improve the “physical capacity” of healthy people. It increases blood flow, which improves exercise capacity in athletes.

Performance Enhancer

Off – label use of Meldonuim in healthy people: increasing exercise tolerance, learning, memory, and even sexual function. One athletic Biohacker reported enthusiastically

"I play ice hockey, tennis and I do weights training and yoga. I have personally taken Meldonium... before weights and yoga training... before ice hockey, and the benefits are immediate : more energy, no hunger, feeling light, as if my body was not heavy, also feeling really concentrate and aware and brain's functions seems enhanced. I could also add that this drug, make you not wanna lose, seems like it has a mental effect that keep you pushing more and refusing to lose or giving up and makes you wanna give your best until the end even in a losing game/match up."

Banned from the Olympics

Wada (World Anti-Doping Agency) found “evidence of it's use by athletes with the intention of enhancing performance” by virtue of carrying more oxygen to muscle tissue.

The decision to add Meldonium to the banned list was approved on September 16th, 2015, and it came into effect on January 1st, 2016. Wada had spent the previous year monitoring the drug before adding it to the banned list.

Meldonium gained popularity after Maria Sharapova, a famous tennis player, from Russia, said that she has been taking this drug for the last 10 years for health reasons. Also, a number of other world and Olympic champions admitted to taking it...

Performance Enhancers - Limitless Mindset

Semen Elistratov

Maria Sharapova

Ekaterina Bobrova

Eduard Varganov

Aleksey Lovchev

Abeba Aregawi

• World record holder in short track – Semen Elistratov
• Olympic champion figure skater – Ekaterina Bobrova
• Racing cyclist from team Katyusha – Eduard Varganov
• World champion weightlifter Aleksey Lovchev
• World champion runner from Sweden – Abeba Aregawi

Although professor Michael Joyner of the Mayo Clinic expressed some skepticism that it was a real hardcore athletic Biohack: 

"Evidence is lacking for many compounds believed to enhance athletic performance. Its use has a sort of urban legend element and there is not much out there that is clearly that effective. I would be shocked if this stuff [meldonium] had an effect greater than caffeine or creatine...”

Research

On Pubmed, you can find 25 clinical trials which evaluated it in humans. To summarize the findings

• The most recent trial done in 2016 evaluated it in healthy Chinese people. The study called Mildronate is an agent for cardioprotection and neuroprotection.
• A study of 49 patients called it an Adaptogen and found that it made the Russian winter a bit more sufferable and improved quality of life.
• It aids recovery from myocardial ischemia.
• Another 2014 study of middle-aged and elderly evaluated the effect of oxidative stress on meldonium, hemodynamics and quality of life of patients with cardiovascular disease (CVD) in extreme climatic conditions (summer heat). It also concluded that it had an adaptogenic effect, it improved response to oxidative stress 
• A recent trial of 140 patients Early use of meldonium decreases probability of emergence of fatal arrhythmias and improves prognosis of hospital stage of rehabilitation of patients with acute coronary syndrome.

The evidence is better for its physical performance enhancement effects, evidence of its potency as a cognitive enhancer is not significant. It won't be my go-to Russian smart drug.

Side Effects

The recent Chinese study reported No serious adverse events were observed. A 2015 trial of 67 Russians agreed No side effects were registered during the course of mildronate treatment.

Like Semax and Cerebrolysin, Mildronate is on the Russian List of Vital & Essential Drugs.

Country of origin: Latvia

Swiss Chems in the USA offers MK-677 capsuled.

Biohack Review: Build (and preserve) muscle, like a boss!

If you'd like to take your workouts and fitness to the next level but are a bit confused by the dizzying number of supplemental options (some of dubious safety) for doing so I'll simplify things for you: take HMB and Creatine. Here I'll review HMB and break down the recent science done on it.

Biohacker Review: Yohimbine superpowers sex and workouts with adrenaline!

Day 1
I did 5 milligrams, a low dosage, on a Sunday afternoon before a gym session with my wife. I had a good gym session but my performance was not extraordinary.

Day 2
I upped the dosage to 10 milligrams, which I did on an afternoon while I was doing some writing. I did find it stimulating but not overly so. I had a productive afternoon. I don't think I'll be reaching for Yohimbine to stimulate me to do my digital laboring. It doesn't seem to enhance cognition or creativity the way that Adaptogens or the Racetams do. The adrenalin release does me make feel a bit on edge which I don't really need.