The pharmacological mechanism of action of the piracetam-like nootropics is still obscure. Their unique feature is that they exert distinct effects on memory, but show hardly any biochemical activity and are practically devoid of toxic effects. Our results indicate that the memory-enhancing action of these substances is dependent on the presence of the adrenals, suggesting that their central effects...

OBJECTIVE: The objective of this study was to investigate the effectiveness of Bacopa monnieri Linn. for improvement of memory performance in healthy older persons.

Abstract: Functional magnetic resonance imaging was used to investigate the relationship between cortical activation and memory load in dual tasks.

The frequency of working from home has been rising rapidly in the US, with over 10% of the workforce now regularly work from home. But there is skepticism over the effectiveness of this, highlighted by phrases like "shirking from home". We report the results of the first randomized experiment on home-working in a 13,000 employee NASDAQ listed Chinese firm....

Abstract Methamphetamine (MA)-dependent individuals exhibit deficits in cognition and prefrontal cortical function. Therefore, medications that improve cognition in these subjects may improve the success of therapy for their addiction, especially when cognitive behavioral therapies are used. Modafinil has been shown to improve cognitive performance in neuropsychiatric patients and healthy volunteers. We therefore conducted a randomized, double-blind, placebo-controlled, cross-over study,...

AbstractMETHODS:Various developmental problems including attention-deficit/hyperactivity disorder (ADHD) have been linked to biological deficiencies in polyunsaturated fatty acids (PUFAs). Additionally, there is evidence that symptoms may be reduced with PUFA supplementation. This study investigated effects of supplementation with PUFAs on symptoms typically associated with ADHD. Because nutrients work synergistically, additional effects of micronutrient supplementation were also investigated. A total of...

1. The effect of the nootropic drug oxiracetam on hippocampal neurotransmission was investigated in the CA1 region of the rat hippocampal slice in vitro by use of extracellular recordings. 2 Superfusion of oxiracetam (0.1–100 μm) produced a concentration-dependent, wash-resistant (>90 min), increase in initial slope and amplitude of the dendritic field excitatory postsynaptic potential (e.p.s.p.). This increase was maximal...

Abstract Hypothesis. Withania somnifera is an herb with antioxidant, anti-inflammatory, anticancer, antistress, and adaptogenic properties. Previous studies have shown its antistress effects in animals. Traditional Indian medicine has used it for centuries to alleviate fatigue and improve general well-being. METHODS: This is an open-label prospective nonrandomized comparative...

Abstract The current study examined the efficacy of heart rate variability (HRV) biofeedback using emWave, a publicly available biofeedback device, to determine whether training affected physiological tone and stress responses. Twenty-seven individuals aged 18-30 years were randomized to a treatment or no-treatment control group. Treatment participants underwent 4-8 sessions of emWave intervention, and all participants attended pre-treatment...

The effects of the nootropie drugs Piracetam (Pir) and Pramiracetam (Pram) were evaluated on recognition-memory of rats in a new one-trial test. This test is based on spontaneous exploratory activity and does not involve rule learning or reinforcement. Recognition is measured by the time spent by rats in exploring two different objects, one familiar (the sample), the...